Issue
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Support Core plugins from 2.42 to 2.44 performs histo:live requests periodically thus a FullGC is also performed. 
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Jenkins instances requiring more than 10G of heap could face slowness issues because of the FullGC. 
Environment
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CloudBees Jenkins Enterprise - Managed controller (CJE-MM) 
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CloudBees Jenkins Enterprise - Operations center (CJE-OC) 
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Support Core plugin from 2.42 to 2.44 
Resolution
Upgrade Support Core plugin to 2.45.1 or higher.
Since 2.42 to 2.44, a new component requests the memory histogram for live instances. In order to generate the histogram, the jvm performs a FullGC. That behavior cannot be disabled when the bundle is generated in background.
Support Core plugin 2.45.1 disables the histogram generation by default, but can be enabled:
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temporally running com.cloudbees.jenkins.support.impl.HeapUsageHistogram.DISABLED=falsefrom Manage Jenkins / Script Console
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permanently adding -Dcom.cloudbees.jenkins.support.impl.HeapUsageHistogram.DISABLED=falsesystem property